Manchester United lost 3-1 on Leicester in the crucial FA Cup quarter-final tie.
OGS was criticized for selecting a second-string squad but he remained adamant about his choices.
“I would have started the same team again. We felt [Pogba and Van de Beek] had more than 45 minutes in them,” he said.
“We picked a team that we felt was going to win the game or give us a foundation to win the game.
“We knew players like Donny and Paul wouldn’t last more than an hour.”
“Every team selection has reasons behind it. Bruno has played very, very much football,” Solskjaer said.
“The boy is a human being. He has played a game every three or four days.
“It was a chance to start both Donny and Paul. The accumulation of games maybe caught up with us.
“With Bruno, I know he wants to play but sometimes you make decisions for the benefit of both the team and him.”
“I think the international break will give Paul and Donny chances to play, it’ll give Anthony [Martial] a chance to go away,” he said.
“They will get a change of scenery. You get energy from that. The boys have been at Carrington training ground now every day for a long, long time.
“The break comes at a good time and we’ll be ready at Easter, don’t worry about that.”
Solskjaer added: “If and when we’re successful, we have to handle [fixture congestion] and hit a higher level than we did today.
“That’s what we’re striving towards and, under these circumstances, which are unprecedented, I’ve been impressed by my boys.
“They’ve been excellent. The run we’ve been on has been excellent. Unfortunately we couldn’t find our normal selves tonight and sometimes that happens.”